故事是发生在1895年的加拿大，主人公默多克是个年轻英俊的侦探，他的破案手段在当时看来都是非传统的，但却破获了一宗又一宗案件，他的上司虽然对他破案手法不屑一顾，但每次破案后又对自己有这么一个下属感到沾沾自喜，但病理学家却对默多克的破案手法很是欣赏，同时为他破案也提供很多帮助，而默多克也对她日渐迷恋，但又难以启齿。新一季默多克将同时侦破一桩失踪案和一宗凶杀案，拉开新的一章。他在三个小伙伴的帮助下当然会继续用别人不理解的手段侦破案件。他左右摇摆的上司又会在新的剧集里对他怎样挖苦和挑剔呢？

默多克侦探和奥格登博士前往温哥华岛拜访默多克的兄弟、加拿大皇家骑警警官贾斯珀·林尼。在那里，他们调查了一起与一名考古学家有关的谋杀案，该考古学家发现了一个古老的土著定居点，导致与松希族和海达族的遭遇。与此同时，布雷肯瑞德一家获得了一个投资机会，但情况可能并非如此，克拉布特里和希金斯计划与他们的恋人尼娜·布鲁姆和露丝·纽瑟姆一起滑雪度假，这可能比预期的更危险。

Set in Toronto at the dawn of the 20th century, Murdoch Mysteries is a one-hour drama series that explores the intriguing world of William Murdoch (Yannick Bisson), a methodical and dashing detective who pioneers innovative forensic techniques to solve some of the city's most gruesome murders. Murdoch’s circle of associates includes Constable George Crabtree (Jonny Harris, Hatching, Matching and Dispatching), Murdoch’s eager and often naïve right-hand man; Inspector Brackenreid (Thomas Craig, Coronation Street), Murdoch’s skeptical yet reluctantly supportive boss; and the love of his life, pathologist-turned-psychiatrist Dr. Julia Ogden (Hélène Joy, Durham County), a staunch ally who shares the detective’s fascination with forensic science and innovative ideas. All are valuable allies who help Murdoch solve his varied cases and traverse the many stratums of Victorian-turned-Edwardian society.